hey, i have worked out with the M100 and yes it is possible...however, in my personal opinion, you are better off with in-ear headphones for working out & jogging.
from my personal experience, the headphones would slip around a lil bit (not much, but just enough to be slightly annoying). my ears got really hot & stuffy under the earpads, which caused me to start sweating earlier. when I started sweating the headphones got really uncomfortable to wear. however, i don't think these issues would be specific to the m100, but rather to overear closed headphones in general.
I do think that out of all the closed headphones i've tried, the m100 would seem like the best one to exercise with as it has a very tight clamp & is made of very durable materials, so I wouldn't be as worried about dropping them. only slight drawback is that these headphones are a bit heftier than others due to the metal construction.
Edit: I think that the Sennheiser Momentums would be a pretty good choice for exercise headphones. they are incredibly light & very small... has real leather earpads that are more breathable & more on-ear than over-ear, so your ears probably wouldn't get as stuffy.
M-100s are more secure on my ears than most IEMs unless they have ear hooks.