You should start low on gain and see how it sounds. If you feel something is missing, then go up one step until you find your ideal sound. I use low impedance headphones with my E17 (V-MODA XS/M-100) and I find 0 Gain to be too quiet, 6 Gain to give me the most dynamic sound, and 12 gain to be, for lack of a better word, "noisy." Each level up in gain changes the volume noticeably, but the finer details in the sound are what you should be listening for.
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