As for fatigue, unfortunately yes, they are fatiguing. Not because of the sound, but because of those damned dimples in the head band. I'm bald, so those dimples compress directly into my head leaving irritating and visible indentations, much to the hilarity of my girlfriend. My solution is going to be getting hold of a small bit of memory foam, cut it to size and bond it to the underside of the head band.
All in all very happy with the new 'phones
There are several options for removing the bumps. Personally, I just ripped the entire headband off and duct taped a hand cloth to the top. Another poster used one of those seat belt cushion straps...or was it a child safety belt strap...don't think it matters.