Looking for new audio interface with mid-range budget

I'm re-writing this response.  You're trying to do many different things from inside one box.  I would split the midi to its own box, then focus on a good i/o box that can also drive your Genelecs.  

For recording/playback/monitoring I'd look at the Apogee Duet 2.  Apogee is on a par with ProTools when it comes to D/A and A/D converters.  I didn't recommend this box at first because the first Duet 2 sent to me had a problem producing accurate upper frequency sound.  It was crushing the highs and cutting reverb down to a mute level.  Apogee sent me a replacement and it made all the difference in the world.  It has 4 channels out (1 balanced pair for your Genelecs, and 1 balanced pair for headphone monitoring) 2 inputs can be mic or line level.

On the output side, it does the job well-- though not quite to audiophile standards.  I drive my Genelecs through a Burson 160D converted to balanced through an ART CleanBoxPro.  The Duet 2 is a bit muddy in the bass area by comparison, but it goes note for note against the Burson in the mids and upper frequencies.  Soundstage is neutral on the Duet 2.  Through the Burson, the soundstage is wide and open.  In my opinion, it's worth the cost savings to give up the bass extension, because you gain inputs and the slickest interface ever made.

The Duet 2 also has 2 audio inputs, balanced and/or unbalanced with a mic pre amp if you plug the box in.  There are two assignable touchpads on the interface and a large wheel for level changes, selectable by pushing it down.  One of the slickest interfaces I've used in that regard.  It's a ridiculously sexy interface.  

Best of all, it's great sound for a portable rig.  You can throw it in your bag and have sweet sound anywhere through a set of headphones.  Take that, Burson!  

The box runs in the $550 to $700 range.  I got mine from Sweetwater.  

Alternately (and cheaper), for just mic input, you could pick up the CEntrance MicPort Pro.  As a mic-pre, it's incredible (only 1 channel, though).  CEntrance A/Ds run lock-step with gear several times their price.  It runs around $150, but it won't solve your output problem.  For that, use your audio output of your computer through an ART CleanBoxPro, which is a steal at $65 dollars.  It's a wonderfully quiet unit that's transparent, what you put in, is what you get out.

On the MIDI side, any cheap MIDI interface will do, because you're just moving data through the cables.