Want to ditch the pc and create a home setup. advice?

Why don't you build yourself a nice media PC?  Here are some good links on how to get started.

http://www.computeraudiophile.com/content/Computer-Audiophile-Pocket-Server-CAPS-v20

http://www.goodwinshighend.com/silentmusicservers.htm

There are a lot of nice CDP options depending upon your budget.  You can also get a perfectly fine turntable for $400-500ish if you plan on listening to vinyl.  It's hard to respond to your request without more context.  You don't even mention if you want to listen to headphones or speakers.

Hmm, gotcha, so basically you want a nice stationary system to sit/lie down to and just enjoy music.

Since it sounds like you don't want to do that where your desktop computer is setup, my recommendation is that you have two options as your source:

- Notebook computer or iPad 2

- CD Player

If you have a CD Player, you don't need an external DAC since a good CDP will already have a nice DAC.  I don't use a CDP anymore so I can't point you in a specific direction, but there are a lot of excellent, used CD Players on Audiogon for sub-$1000.  You can get a great Arcam, Meridian, Marantz, Rega, etc., CDP.  Lots of threads you can pull up with a lot of good info with some Googling.

If you plan on using a notebook or iPad 2, you'll want an async USB DAC.  Good ones start at $300-450 such as the Musical Fidelity V-DAC II (make sure not to get the original one) and, presumably (reviews aren't out yet, so keep an eye on this one) the Schiit Bifrost with the USB upgrade.

You'll want a good amp after that.  If you want transparency, Headamp GS-1 is a great place to start.  I had a GS-1 for awhile and it handled everything I threw at it very gracefully.

GS-1 performs very well with most headphones, from the Grados to Senns.  You can get great performance from everything from a HD650 to a SR225i without breaking the bank.

It's a good decision if you have a satisfactory CD collection.  The quality brands have very good D/A implementations.  I also forgot to mention Cambridge Audio 740c and Jolida JD-100a.  Great players but not really to my personal taste.  If you can swing $1000 for a good CDP, it'll serve you well for a very long time, and if you take care of it, you can sell it and retain most of the resale value.  If you go cheap and spend too much time on these forums, you'll just be dissatisfied several months later, and end up wasting time and money upgrading to something you should've bought in the first place.

Any one of those CDPs above (Arcam, Meridian, Marantz, Rega) will be an excellent source, so you want to pair it with a good headphone amp.  Again, I'd highly recommend the Headamp GS-1 or try to find a good price on a used DIY beta-22 (3-channel).  That will give you an excellent foundation that the vast majority of headphones will perform well on.