I don't own either of the two headphones listed, but from everything that I have read, the HD598s have one of the largest soundstages of all the Sennheiser phones.
While the HD650 are a technical upgrade, they have a very different sound compared to the HD598. The HD650 will be warmer (more focus on the lower end) while the HD598 will be brighter (more focus on the upper end). Depending on your preferences, you might not like the one, but love the other, or you might enjoy both for the different sounds, so it really depends. As stated, from pure a specifications and technology standpoint, the HD650 is an upgrade, but I do not think it is worth the price since I personally prefer phones with a brighter signature (though the HD650 are still, undoubtedly, a fantastic pair of headphones). Also, the HD598 is no where near as amp dependent as the HD650, but that might be moot depending on what your current set up is.
Edited by fusedpro - 8/15/11 at 7:10am