People talk about "listening fatigue". The best way to induce listening fatigue is to wear sealed headphones and listen to tracks with boosted ultra high frequencies. It won't sound any different than a balanced frequency response, but you'll get a headache quick.
When I was a kid, I hated to go to Sears because the whole store was lit by banks of fluorescent lights as far as the eye could see. I could barely hear the squeal of all of those ballasts, but I sure could feel them in my head! That squeal is somewhere around 14-15kHz. Pain!
man i get the same thing from old style analog tv's. in fact i can't watch tv much do to the high pitch squeals they cause. luckily lcd doesn't do that.