You've had some good answers here. I think the best advice is to focus on the speaker/amp match. If you've got neither, then buy them based on finding people who are highly experienced with combinations. This is especially true with low-wattage amplifiers, where the speakers can make or break the success of the system.
For instance, I'm currently building a pair of OTL amplifiers based on the Atma-Sphere M60 design (circlotron). These amplifiers are fully balanced, dual-differential triode amplifiers where the speakers are hooked up directly to the output of the tubes with NO output transformers. Unfortunately, they do not sound very good with speakers that have low impedence, especially if the impedence curves over the frequency spectrum are uneven, or drop below 4 ohms at some frequencies. OTOH, with 16 ohm speakers they can sound divine! I heard them with a pair of high-efficiency wave-drive horns (Audiokinesis PlanetarIum Beta's) and was totally blown away by how REAL the music sounded. I could reach out and inspect Norah Jones' tonsils. But the same amplifiers powering a pair of PSB speakers sounded very average, and uninvolving.
Some of the really great pairings I have heard and spent lots of time with include:
* McIntosh MC225 (25 watts per channel) paired with original Quad 57 electrostatic speakers
* McCormick DNA amplifiers (250 watts per channel) paired with Vandersteen 3a dynamic speakers
* Airtight tube amps (high power) paired with SoundLab A1 electrostatic speakers
* McIntosh MC2102 tube amps (100wpc) paired with Joseph Audio small towers -- don't remember the model
* Sandersound Magtech (300wpc) paired with Magneplanar 3.6 speakers
* Atma-Sphere S30 (30wpc) paired with Audiokinesis Jazz Module speakers
Of course this is based on my criteria for good sound, which probably differ from yours. But most of these represent concensus viewpoints among owners. Watts seem to have very little to do with the "goodness" of the results. But synergies between power transfer functions of the amp and speaker sensitivities at different frequencies have a LOT to do with the quality.
Hope this helps!
Frank