He's observing that you're putting the noisy AC line in pads and the even noisier diode bridge right next to the high-impedance U2/Q5/U1+IN node. This will wreck your regulator's performance.
You want all the AC stuff to be shoved over entirely to one of the short board edges, and the high-impedance op-amp nodes and fully-regulated DC outputs over on the other. 00940's relayout helps, but I'd try to push the DC output connector clear to the left. Don't get caught up doing contortions to get this to single-sided. This is a high-performance regulator; don't nerf it.
You might even consider going 4-layer.