The Grado pads drove me crazy for a few weeks. I found my SR325is stock bowls to be comfortable for a 2-2.5 hour listening session. But then I found myself listening to my Grados for more than 4 hours every night (I absolutely love the sound) and that caused discomfort.
I tried everything from comfys, HD 414 quarter modded pads, flats, G cush pads, but nothing provided long time comfort. So I went one step ahead and tried different pad mods.
The radio shack mod (I found this somewhere on Head-fi). I found this to be the best compromise between the SQ and comfort. Punch some holes in radioShack's headphone pads and fit the bowls over em. My bowl pads softened after use and the shack pads do not let my ears rub against the drivers.

I recently purchased the BrainWavz HM3 and they came with a spare set of pads, which I used to get this:

I put the HM3 pads over HD414s. The SQ became veiled and distant, so I enlarged the quarter sized hole of the HD414s and cut off the foam of the HM3 pads. Fits around my ears and has great comfort for a Grado!