Depends on the headphones. Average to high sensitivity and low to medium impdance can be driven acceptably, but 250 Ohm might already be stretching it a bit. Ideally an amp is used along with the Titanium HD. People have reported good synergy between the Titanium HD and the FiiO E9, as each device's signature complements each other nicely.
Hmm. Maybe I'll try out the Titanium versus my Xonar DG and see if I can notice a difference. If not, Amazon usually treats me really well in regards to returns.