I just recently got a pair of M6's. As I am fairly new to this community and unexperienced with different sound sigs, I can only attest to the isolation and comfort of these phones.
Isolation - I had them on this morning and was amazed that I can barely hear the subway train as it pulled up to the platform, I was about mid volume on my player.
Comfort - I have never used iems until these but once I got a proper seal, I barely noticed these. I usually only have them on for about an hour at a time, but I definitely do not see these getting uncomfortable during lengthy usage. Of course I did need to do some fiddling around with teh memory wires but once I got them set up, it was smooth sailing.