Well the configurations are all on AMB’s site, in summary the three main options are 2-channel passive ground (2 boards), active ground (3 boards), and balanced (4 boards). Then you have to decide whether to put the transformer/psu into the same chassis or house it in another enclosure away from the amp boards. The transformer is a electromagnectic interference (EMI) and can cause the amp to hum, unlike the M3 the beta22 is prone to be more problematic in a one chassis build, so be warned.
The advantages of each configuration is up for debate and there is no easy answer. Have a look here under configurations:
http://www.head-fi.org/forum/thread/503443/the-22-threads-thread-help-yourself
As to ventilation, it depends on which configuration your going for, AMB have thermal calculations available, but you’ll have to be more finalised with your parts selection to get a good idea, it’s not as easy as looking at that pic and making a quick decision.
Edited by johnwmclean - 9/14/10 at 12:09am