It would depend on if you just want to stuff a board (full kit) or learn to do a BOM.
I really like my Pimetas (both V1 and V2). They are portable, but you can plug them in. But you have to do up a BOM and order you own parts.
Glass Jar has the Mini3 which could be use as a desktop amp if you kept it plugged in.
Increasing the challenge a bit would be a CK2III. I personally haven't built one, but I like the design a lot. I'm building an amp based upon the original Kumisa III.
If you want to open you choice to tubes as well, there is more options available as kits. There doesn't really seem to be a desktop SS kit that I've seen, unless you want to go all the way up to a beta22.
As for the USB input, it would depend on how much space inside the case you want to dedicated to it. You could put a BantamDAC or grubDAC in many cases pretty easily. If you have more space, a gamma1 gives you SPDIF as another input.