Looking through the vent, I can see everything is attached to the top plate :. it appears that I would indeed turn it over and open the bottom to get to the loose screw. There is a loose screw inside. So I did pull it out of the housing. Hopefully I didn't strip the housing. Before I attempt this, I had a couple questions. Are the components sensitive to static (should I take precautions?) Can I just lift it to the floor and do it on the carpet right below where it is or should I carry it down to a workbench?
Also, my uncle has a neighbor that used to do DIY stuff as a hobby (now he just remodels his house in his spare time)...since everything works I just need to tighten a screw, should I wait until he's available since he would know what he's doing, or is this going to be as simple as replacing a video card?