Either way, Firestone claim in their new USB isolation dongle sales pitch that "the noise from the power lines has effected the data integrity creating problems with the timing of the digital signal, known as jitter."
and this link says: http://hifiduino.wordpress.com/2011/11/24/which-digital-isolators-for-i2s-or-not/
"Galvanic isolation of the I2S output from the FPGA core and the USB ground virtually eliminates jitter and common noise originated by the PC."
OTOH, all those I2S isolators distort the signal to some extent...so it's never a black or white story I guess. IME, non-isolated coax sounds good off the Asus ST..but it's a potential groundloop feast. I think isolation is a necessary evil, and depending on your gear it can either outcome the cons or ever so slightly worsen the SQ indeed, but no groundloop!
And I'm using speed pots on all my fans that use PWM(pulse width modulation), it seems to be a very noisy method to throttle fans speed...moving them to a discrete PSU should be salutary 