Tao was my favorite club when i went years back, but it depends on how much experience you have in dance clubs cause in Vegas they can look useless and stupid or amazing pending your expectation level. mine is a bit high so i really didn't like most of them..so i just drank and drank to make up for the disappointment, which worked out great cause i got to play duck/duck/goose with everyone waiting at the bar without getting knocked by someone..
I would recommend you stay at a Hotel in the middle of the strip if you plan on walking the strip and visiting the different hotels, i stood at the Mirage and have no complaints but it was an older crowd there which you may not like (i loved it cause i felt younger and in turn acted even dumber).
if you or your friend likes to shop there are two or three great places to go, i only made it too Caesars Palace before ruining my credit card.
the pools are cool for relaxing but be warned about those sweet & tall drinks they serve, they are expensive and loaded with alcohol (which may be a good thing, in my case it was)
anywhere in Vegas you'll need money, even if its just for basic's and food its still going to cost you so bring a good amount of spending money with you..really Vegas is the one place you can't really do anything without spending money. even sitting by the pools or walking the strip will cost you in drinks/water.
if you are not much of a gambler but just wanna do a bit of it cause you are in Vegas then go early mourning as the Tables are lower priced, if you want to hit the machines go late night cause they are empty. if you hit the tables early you can find alot of really nice dealers that will teach you how to gamble and have fun without being stupid..and remember to tip your dealer when you leave the table.
walk the strip in the evening, its really a sight to see with everything lit up and all the different kind of people around you, just remember there are always wolves in the pack waiting to snag an easy target, basically be smart about your looks, who's around you and where on the strip you are (you'll know when you get to the rougher parts). also since your friend is a girl you may want to keep that extra eye on which arm her purse is hanging/being held. Vegas is safe at night just don't think you're at Disney World.
have fun and spend alittle money but remember to relax and go with the flow after all whats happens in Vegas stays there!