If you don't know how to use the plugin, just don't use it... It took me months to set it up perfectly to my ears and now I feel like walking in heaven when listening. Absolutely natural sound with balanced sound layers (that means you will definitely loose some amount of detail in order to get a proper simulation of environment around you) :-)
It is also good to mention that I don't like TB Isone as much as Isone Pro (previous version of this software). So I can only definitely recommend trying Isone Pro.
Why not go through every setting used.