fleabag, you read the manual??? Heck, I haven't even done that. I am impressed. You should have no problem with sampling rate. I have plugged into various players, and the DEQ just resets itself. Interestingly, the digital output sample rate always equals the input rate. That makes me suspect that it operates at whatever the source frequency is all the way through (no sample rate conversion going on).
Tomek, I agree with ooheadsoo on the best treatment for room acoustics. Use of acoustic treatment and careful placement is more effective that equalization. The problem with eq is that room response variations are caused by unwanted reflections. By simply adjusting the amplitude you will get the level more uniform, but the level of reflection relative to source (speaker) will remain the same. This plays hell with image and detail.
HOWEVER, having a mic and rta is extremely useful in helping resolve the room issues. The eq is also useful for broad level matching. For example I have a system with a broad sag in the response from 2 Khz to 7 Khz. I use a wide parametric centered at 5 K to pull it up a few db. It is also safe to eq low frequency peaks. It is not good to try to fix lf valleys (a very strong null may require HUGE amounts of boost, straining drivers and amps, and creating problems elsewhere in the room). Dr. Toole has a good white paper on the subject over at the Infinity website.
Sorry, I tend to get verbose on this stuff. Bottom line: I think that a DEQ with mic would be a very valuable tool in setting up a speaker system in a room. It has certainly been an ear opener for me

I am in the process of setting up a room and speakers. I stumbled across something seemingly remarkable. Sort of a new twist on an old concept (think Roy Allison). It eliminated a lot of room acoustic issues. I hope to write it up this weekend.
gerG