Added to end of the OP
UPDATE #2 - ROUND 3: Revenge of RE0, ER-4P dethroned!
After the experiments with various tips I was intrigued – how would properly tipped RE0 stand against Etymotic? I also thought that there are many head-fiers with portable amps and very few with the custom tips. So the second question is – how does RE0 stands to Etymotic when both are amped and equipped with universal tips?
I was not willing to make over the whole comparison step by step. Instead I decided just to listen to some of my favorite songs. I attached transparent bi-flanges to RE0 since they sound closer to Etymotic. I attached tri-flanges on ER-4P, compared both RE0 and ER-4P unamped from Classic…
RE0 + bi-flanges beat ER-4P + tri-flanges, when driven by Classic!
Well, tri-flanges are not the best sounding universal tips for Ety. So I changed them to the black foam for ER-6 (ER6-14F). I do not like ER-4P black foam (ER4-14F) because its wide inner tube makes the highs too spiky for me. ER6-14F inner tube is narrower thus highs are softer. BTW, I’ve read somewhere at head-fi that Etymotic changed the inner tube of ER4-14F recently to the narrower one, nice move.
ER-4P + foams beat RE0 + bi-flanges, when driven by Classic.
I think that latter is not fair comparison indeed. Foams are not portable solution. You have to squeeze the foam by the fingers which are not clean when you are outside. Foams are also scratchy and do not last long.
Then I went amped. Source was Classic with LOD, amps were Meier Move and Xin Supermicro IV w 4/11 mods. RE0 kept bi-flanges and I tried ER-4P with both foam and custom tips.
RE0 + bi-flanges beat ER-4P + either tips, when amped!
Amped RE0 does not yield ER-4P in terms of speed and details, while supersedes it in terms of clarity and tonal realism.
Wow! ER-4P is dethroned by dynamic canalphone made in China. Lets the flame begin…
Do not hurry guys. There is still ER-4S left and I am its long time fanboy. I spent a lot of money and so much time modding my Ety to death. I went through numerous rebuilds of silicone custom tips. I carefully chose the most synergetic portable amp for them (Supermicro it is). I even recabled them with OFC (I made all the comparisons with stock Ety cable). So it is not easy for me to sustain a defeat. See my ultra modded ER-4S below:

There is no obvious winner between ER-4S and RE0 for me right now. Amped RE0 with bi-flanges gets dangerously close to ER-4S, featuring very fast transients, good details, better bass proportions, more realistic mids. I feel that ER-4S is better by a hair … or by a split of a hair. But it is not easy to detect and harder to describe yet.
The final round (ER-4S vs RE0) will definitely take some of my time. I do like to have as few cans as possible. So I am really interested to determine the winner and let the loser go. Since I already maximized the SQ of my ER-4S, I should give my best efforts to RE0 also.
Stay tuned.