I work in a similar cube farm environment and although the HD-280 Pros are my first closed circumaural headphone, I would definitely buy them again. I wear glasses too and have a relatively big head. Some days the phones do feel tight after a few hours, but they are loosening up now after 9 months or so... The isolation alone is so nice that sometimes I wear them without any music playing. They are also great for lawn mowing since they attenuate like 30dB of outside sound! I'm a musician too, and these are also great for wearing while recording vocals too.
I'm enjoying this thread too, it makes me want to check out the DT770s.