Originally Posted by IPodPJ
It shouldn't, but that doesn't mean it isn't. Different sources output at different voltages, introduce noise into the line, have different output impedances, etc. I didn't think a better digital cable would make a difference, but it does. A good transport is a very important part of the chain.
Well, my logic used was that kelvinz mentioned that he is using optical, so these issues shouldn't apply. You are right about the quality of output possibly being different though, I should have thought my reply through a bit more- the stability of the clock on the source and the quality of the signal LED might have an impact on the sound.
Coax is usually better than optical but the electrical isolation provided by an optic cable cuts down on noise prevalent in computers.
All I can really say is: try both.