When I'm using my laptop with its godawful speakers I ramp up the lower mids about 3 or 4dB (this is by ear though so don't quote me on that) and I have been known to turn down the high freqs a bit because the crappy little inbuilt speakers love to accentuate 5k and above.
The desktop is kept clean and zeroed across the spectrum though, sometimes I +3dB on 29 and 58Hz via hardware EQ on my I/O card's drivers (HD650s are a touch bass light for me sometimes depending on what I'm listening to), but I switch that off for when I'm monitoring with my speakers.