Try a Prairie Dog, Tequila and Tabasco, 1:1. You'll never forget it.
When visiting the tiki bar a town over, I like to have a Samoan Fogcutter. Yeah, it's a foo-foo drink, but you have to have at least one.
My standard mixed drink for weddings, conferences, office parties, etc. (where decent beer isn't available) is the Greyhound. Vodka and grapefruit juice on the rocks, highball. Try one. They're refreshing, not sweet, and I'm usually OK in the morning if I stick to them.
Out to dinner or just out for drinks, I usually stick to beer. Micros, always, and I go for IPAs, stouts and porters. A good martini (standard gin/vermouth, olive, shaken, no flavored crap) hits the spot, too. As does a nice cab or pinot. But mostly, I'm a beer guy. Don't just drink the standard American junk, try a variety of micros. They're better and don't be afraid of the dark ones. They're not bitter.