The sub-woofer does not have any amplified speaker outputs, so it can't drive speakers.
You might be able to hook a small speaker amplifier between the sub-woofer's line-outputs and whatever un-powered speakers (Klipsch?) you might get.
Here are some smaller amplifiers.
So you would just run a cable from the motherboard's on-board audio's Front Speaker jack, to the line-outputs, on the sub-woofer.