Well, Wodgy, here is the exact quote - you tell me if I've misread it:
"If you use hi-fi speakers as near-field speakers, for best results mount them horizontally, not vertically, with the tweeters at the extreme left and right sides and the woofers in the middle. The speakers should also face inwards slightly. When mounted this way, the highs (which are directional) have maximum separation, while the low frequencies (which aren't so directional) emanate more from the middle."
http://www.alesis.com/support/cc/speakers.html
I figured it was a cheap tweak - if it ruined the sound, I could re-orient the speakers without much cost :-) But the truth is, I think the sound improved some - at least imaging improved. They look a little funny, though.
I don't know about the "lobing" effect.
I'm sure the sound would improve if I could minimize reflections off the desktop. Not sure how to do that, however.